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What Causes a Polyp to form in the Liver?
In the liver, and presumably also in other organs, tumors are common. They develop according to the same genetic (epi)genetic instability as sporadic cancers, and are driven and maintained by the same oncogenic somatic mutations, such as the activation of APC by the proto-oncogenic, germ-line mutation that causes Familial Adenomatous Polyposis. The somatic mutation that causes this epigenetic instability, which we call “Somatic Epigenetic Instability” (SEI), is a hallmark of many sporadic cancers. If SEI is not present, a genetic lesion that would normally cause a benign lesion results in a benign phenotype instead. If, on the other hand, SEI is present, a genetic lesion that would normally result in a benign phenotype results in a malignant phenotype. Thus, many of the common cancer mutations increase the likelihood of SEI. The fact that these mutations and events are common in nearly every cancer, even those of different organs, strongly suggests that SEI is an epigenetic instability common to nearly every human cancer. In addition to APC loss, other examples of SEI include:
K-Ras mutations, which are common in many cancers.
DNA hypermethylation, which is often associated with cancers.
Loss of heterozygosity (LOH), which is common in many cancers.
This information is not intended as a replacement for diagnosis, treatment, or medical care. It is provided for informational purposes only. It does not constitute a replacement for professional medical advice, examination, diagnosis or treatment. Never ignore professional medical advice in seeking treatment because of something you have read on the Internet, as medical advice varies from situation to situation. If you have a medical emergency, call your doctor or 911 immediately.Pave Solar (Spanish:Pavia Solana) is a former municipality of Spain. The official name is now Catedral de Santiago de Compostela; but the Pave is the popular name of the town. The town is the capital of the province of the same name, which also bears that name. As of 2007, it had a population of about
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